2024–2025年SYNLETT 高被引论文
展现对合成有机化学产生最大影响力的研究成果
高被引论文不仅意味着较高的关注度，更代表着那些正在推动有机合成领域未来发展的重要发现、创新方法与前沿观点。
本专题汇集了2024–2025年发表于SYNLETT的五篇高被引论文。这些研究涵盖从三维生物电子等排体、逆合成设计，到光催化、自由基化学以及后期同位素标记等多个方向，充分展现了SYNLETT所代表的研究广度、严谨性与创新性。
探索以下精选论文，了解哪些研究成果正在全球化学界产生最广泛而深远的影响。
01
冯见君，湖南大学化学化工学院
Our most-cited article of 2024–2025 unlocks a new route to molecules that mimic benzene in 3D.
Feng shows how (3+3) cycloadditions of bicyclobutanes provide 100% atom-economical access to bicyclo[3.1.1]heptane derivatives, valuable 3D bioisosteres of benzenes and key structural motifs found in terpene natural products.
02
Mark D. Levin
Why do chemists reach for some reactions and not others when planning a synthesis?
Mark D. Levin argues that "retrosynthetic simplicity" is an underappreciated criterion in methodology design, offering a compelling perspective on how synthetic routes should be evaluated and developed.
03
Recent Developments in Photocatalytic Reduction of Nitro Compounds to Valuable Scaffolds
Sanjit K. Pandey, Bharat K. Sharma, Varinder K. Aggarwal et al.
Photocatalysis is emerging as a cleaner, greener alternative to traditional nitro-reduction methods, enabling efficient access to valuable synthetic scaffolds.
This highly cited review examines recent developments in photocatalytic nitro reduction and highlights the growing role of sustainable approaches in modern synthesis.
04
Mark J. Miñoza, James T. Librando, Shu-Li You Liao
A recipient of the 2023 Thieme Chemistry Journals Award, this article is now among SYNLETT's most-cited papers of 2024–2025.
The authors review how ketone-derived pro-aromatic reagents unlock sp³-rich radicals for diverse transformations, including alkylation, arylation, amination, and deuteration.
05
Jyotirmoy Dey and Manuel van Gemmeren
Introducing deuterium late in a synthesis, without starting over, remains one of the key challenges in isotope labeling.
This highly cited Open Access article details palladium-catalyzed, ligand-enabled hydrogen isotope exchange protocols that enable efficient late-stage C-H deuteration through sophisticated catalyst design and reversible C-H activation.
在 SYNLETT 发表您的下一项突破性研究
本专题精选的论文充分体现了SYNLETT一贯的研究质量、创新性与科学影响力，也正是这些优势使其成为合成有机化学领域值得信赖的学术阵地。
无论您的研究聚焦于合成方法学、催化、药物化学、光催化、自由基化学，还是有机合成领域的新兴方向，SYNLETT都能为您的研究提供一个严谨且具有高度国际影响力的发表平台。
您的研究是否会成为下一篇高被引文章？
