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经典迷幻剂与锂剂同时给药(而非拉莫三嗪)与癫痫发作相关:在线迷幻剂经验报告分析 2021-11-23
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迷幻剂在治疗单相抑郁症方面显示出了希望,尽管最近的迷幻剂试验排除了双相情感障碍患者。正如本期精选论文的作者所指出的,在使用心境稳定剂治疗双相情感障碍的个体中使用经典迷幻剂(如LSD或裸盖菇素)的信息有限。

作者分析了来自三个网站(Erowid.org、Shroomery.org 和 Reddit.com)的使用情绪稳定剂的经典迷幻药的报告。这些可公开访问的网站和在线社区包括用户创建和用户驱动的内容,人们可以匿名分享与迷幻药物使用有关的信息。这些在线社区经常收到“旅行报告”(此后的经验报告),或对迷幻药物经验的描述,通常相当详细。

网站分析显示,62份锂盐加迷幻剂报告中有47%涉及癫痫发作,另外18%导致“糟糕的旅行”,而34份拉莫三嗪报告中没有一份涉及癫痫发作。此外,39%的锂报告涉及医疗护理。大多数拉莫三嗪报告(65%)但很少(8%)锂剂报告被判定为不影响迷幻体验。本报告被视作是初步的,还需要进一步的研究来确定使用迷幻药物的患者在接受锂盐治疗时的显著癫痫发作风险。

诚挚地邀请您阅读本期精选论文和本刊最新一期的其它论文。

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

Nayak SM et al.

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Introduction Psychedelics show promise in treating unipolar depression, though patients with bipolar disorder have been excluded from recent psychedelic trials. There is limited information on the use of classic psychedelics (e. g., LSD or psilocybin) in individuals using mood stabilizers to treat bipolar disorder. This is important to know, as individuals with bipolar depression may attempt to treat themselves with psychedelics while on a mood stabilizer, particularly given enthusiastic media reports of the efficacy of psilocybin for depression.

Methods This study analyzed reports of classic psychedelics administered with mood stabilizers from 3 websites (Erowid.org, Shroomery.org, and Reddit.com).

Results Strikingly, 47% of 62 lithium plus psychedelic reports involved seizures, and an additional 18% resulted in bad trips while none of 34 lamotrigine reports did. Further, 39% of lithium reports involved medical attention. Most of the lamotrigine reports (65%) but few (8%) of the lithium reports were judged to not affect the psychedelic experience.

Discussion Although further research is needed, we provisionally conclude that psychedelic use may pose a significant seizure risk for patients on lithium.

阅读本刊更多论文,请点击这里