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SYNTHESIS | 一种炔烃高效水合和串联转移加氢在水中合成醇的方法 2021-01-22

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SYNTHESIS

Reviews and Full Papers in Chemical Synthesis

影响因子 2019:2.675






Thieme Chemistry期刊Synthesis中国作者精选论文,本期论文来自赣南医学院罗人仕博士和欧阳露博士等人的研究,欢迎阅读。


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An Efficient Hydration and Tandem Transfer Hydrogenation of Alkynes for the Synthesis of Alcohol in Water

一种炔烃高效水合和串联转移加氢在水中合成醇的方法

Nianhua LuoYuhong ZhongJi-Tian LiuLu OuyangRenshi Luo

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摘要 //

A practical and efficient method for the synthesis of alcohols in one pot from readily available alkynes via a tandem process by formic acid promoted hydration and metal-ligand bifunctional iridium-catalyzed­ transfer hydrogenation under mild conditions has been described. This transformation is simple, efficient, and can be performed with a variety of alkynes in good yields and with excellent stereoselectivities. Experimental results showed high catalytic activity, and turnover frequency (TOF) up to 25000. Importantly, this transformation can be conducted in water and is thus green and environmentally friendly.

报告炔烃在温和条件下,从容易获得的炔烃,通过甲酸促进水合和金属-配体双官能铱催化的转移加氢的串联法,在一个罐中合成醇的实用而有效的方法。这种转化简单、有效,并且可以用多种炔烃以高收率和优异的立体选择性进行。实验结果表明,该催化剂具有较高的催化活性,周转率 (TOF) 高达 25000。重要的是,这种转化可以在水中进行,因此是绿色和环境友好的。

关键词 //

alkyne - hydration - transfer hydrogenation - metal-ligand bifunctional iridium

炔烃–水合–转移氢化–金属-配体双官能铱

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