新闻
Synlett | 华东师范大学化学与分子工程学院张剑波副教授 2021-01-15

5fd09df2230d5.png

SYNLETT

Accounts and Rapid Communications in Chemical Synthesis

影响因子 2019:2.006






Thieme Chemistry期刊Synlett中国作者精选论文,本期论文来自华东师范大学化学与分子工程学院张剑波副教授等人的研究,欢迎阅读。


s-0040-1707098-1.jpg

Copper-Catalyzed Stereoselective Synthesis of 2-Deoxygalactosides

铜催化立体选择性合成2-脱氧半乳糖苷

Youxian DongMadina YumaYuling MeiNan JiangGuofang YangZhongfu WangJianbo Zhang

华东师范大学化学与分子工程学院

1.jpg

摘要 //

An efficient glycosylation method to synthesize 2-deoxy-O-galactosides based on a Cu(II)-catalyzed reaction without additional ligand has been developed. The glycosylation was amenable to different protected glycal donors and a wide range of acceptors including alcohols, amino acids, sugars, and phenol, and proceeds with excellent yield and high α-selectivity under mild conditions. The reaction proceeds readily on a gram scale, and its versatility is exemplified in the synthesis of oligosaccharides.

开发了一种基于 Cu(II)-催化反应合成 2-脱氧-O-半乳糖苷的有效糖基化方法,无需其他配体。糖基化反应适用于不同保护性糖基供体和广泛的受体,包括醇、氨基酸、糖和酚,并且在温和条件下以优异的收率和高α-选择性进行。该反应易于在克规模上进行,其多功能性在寡糖的合成中得到例证。

关键词 //

copper catalyst - 2-deoxygalactosides - glycosylation - ­glycals - stereoselectivity

铜催化剂–2-脱氧半乳糖苷–糖基化–糖基–立体选择性

2.jpg


免费阅读原文 >