Gram-Scale Synthesis of (±)-Tylophorine

Dattatraya P. Masal, D. Srinivasa Reddy

We report a practical scalable synthesis of the natural product (±)-tylophorine by using an operationally simple protecting-group-free route from readily accessible starting materials. Synthesis of a cyclic N-acetyl diester compound through cyclization, followed by two key steps (decarboxylation and a Clemmensen reduction), provides access to the target molecule.

One-Pot Efficient Synthesis of Sulfonimidamides from Sulfonyl Chloride

Shi-Wei Ma, Jin Huang, Long-jun Ma, Guang-xun Li

Sulfonimidamides, featuring a hexavalent sulfur structure, are a class of key compounds with broad application prospects in the fields of pharmaceuticals and agrochemicals. However, their applications have been limited due to the lack of economically effective synthetic methods. Utilizing the cost-effective and readily accessible sulfonyl chloride as the initial reagent, this method involves the sequential formation of intermediates, including sulfinamide and sulfonimidoyl chloride, culminating in the synthesis of the sulfonylimidamide compounds. This approach yields sulfonimidamides in moderate to good yields, thereby offering a viable synthetic route for the expanded application of these important compounds.

Quinoline-Based FDA-Approved Drugs: Synthetic Route and Clinical Uses

Devesh Chandra, Sachin Sachin, Shourabh Rav, Upendra Sharma

We report a practical scalable synthesis of the natural product (±)-tylophorine by using an operationally simple protecting-group-free route from readily accessible starting materials. Synthesis of a cyclic N-acetyl diester compound through cyclization, followed by two key steps (decarboxylation and a Clemmensen reduction), provides access to the target molecule.

Supramolecular Chemistry: An Enabling Tool for Asymmetric Catalysis

Laura Cunningham

Asymmetric synthesis and supramolecular chemistry are cornerstones of modern organic chemistry. The combination of both fields to develop new approaches to enantioselective catalysis has gained considerable momentum in recent years. Herein, we highlight some of the advantages offered by various supramolecular architectures over conventional chiral catalysts and reflect on obstacles that currently limit widespread use of supramolecular tools in asymmetric synthesis.

Applications of Luminescent Cyclometalated Metal Complexes as Sensors and Switches

Poonam Kaswan, Mantesh Yadav, Shaila Dhotre, Minakshi Minakshi, Simpi Mehta

Cyclometalated complexes, including those with pincer ligands and other chelating frameworks, such as porphyrin rings and polyenes, have garnered significant attention due to their diverse applications in ion and analyte detection across synthetic chemistry, environmental monitoring, medicine, and electronics. These complexes exhibit fascinating chromic behaviors, including mechanochromism, chemochromism, and vapochromism, which are particularly useful in sensing applications. Of particular interest are their photophysical properties, especially in complexes involving lanthanides, which offer unique luminescent and optical characteristics. Metals such as nickel (Ni), palladium (Pd), ruthenium (Ru), gold (Au), and rhodium (Rh) have been extensively studied in order to understand their photochemical activity and to explore their potential applications in light-emitting devices, photo-induced electron transfer, and sensing technologies. Their vapochromic and mechanochromic properties make them highly attractive for environmental sensing, while their photoluminescent capabilities enhance their utility in optoelectronic devices and practical electronics. This review provides a comprehensive overview of their applications, including gas, cation, and anion sensing. The discussion also highlights the need to incorporate specific examples that demonstrate the unique properties and suitability of these complexes for targeted sensing tasks, further emphasizing their promise in advancing sensor and device technologies.