Thieme Chemistry期刊Synlett中国作者精选论文，本期论文来自天津大学，天津市分子光电科学重点实验室，天津化学化工协同创新中心马军安教授等人的研究，欢迎阅读。

摘要 //

A silver-catalyzed protocol for [3+3] annulation of glycine imino esters with Seyferth–Gilbert reagent was developed. A variety of phosphorylated tetrahydro-1,2,4-triazinecarboxylate esters were synthesized in moderate to good yields and with excellent diastereoselectivities. The dehydrogenation of a tetrahydro-1,2,4-triazine product to the corresponding triazine counterpart was also demonstrated.

开发了一种用 Seyferth-Gilbert 试剂与甘氨酸亚氨基酯进行 [3 + 3] 环化的银催化方案。合成了多种磷酸化四氢-1,2,4-三嗪羧酸酯，收率中等至良好，且具有优异的非对映选择性。还证明了四氢-1,2,4-三嗪产物脱氢为相应的三嗪对应物。

关键词 //

[3+3] annulation - glycine imino esters - Seyferth–Gilbert reagent - triazines - phosphorylation

[3+3] 环化–甘氨酸亚氨基酯–Seyferth-Gilbert 试剂–三嗪–磷酸化