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Call for Paper | Drug Research 2020-05-21
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Drug Research

Discovery, Development, Evaluation and Translational Medicine

Drug Research(原名Arzneimittelforschung)为国际同行评审期刊,稿件处理时间快速,提供新药和成熟药物分子相关的最新研究成果和新药开发评估。

本刊重点关注的是在临床环境所使用药物的开发中,转化医学和生物学发现的应用。药物研究领域的文章和实验数据不仅包括新药研发主题,还包括用于工业化研究和临床试验结果评估的数理统计学方法。

Drug Research每年出版12期,发表形式包括原创性研究论文、评述、评注和短报,涵盖如下领域:

  • 应用于临床试验的分析

  • 化学和生物化学

  • 临床和实验药理学

  • 药物相互作用

  • 疗效测试

  • 药效学

  • 药物代谢动力学

  • 畸形学

  • 毒理学

索引库:

Biobase Beilstein Scopus, BIOSIS, Chemical Abstracts Service (CAS), Current Contents, EMBASE Chemical Abstracts, Emerging Sources Citation Index (ESCI), Infotrieve, MEDLINE, VINITI, EBSCO, ProQuest


Issue 5 · Volume 70 · May 2020- Free Access

Development and Validation of an HPLC Method for Quantification of Filgotinib, a Novel JAK-1 Inhibitor in Mice Plasma: Application to a Pharmacokinetic Study

Zakkula A et al.

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Filgotinib is a selective JAK1 (Janus kinase) inhibitor, filed in Japan for the treatment of rheumatoid arthritis. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of filgotinib in mice plasma as per the FDA regulatory guideline. The method involves the extraction of filgotinib along with internal standard (IS, tofacitinib) from mice plasma (100 µL) using ethyl acetate as an extraction solvent.

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The Population Pharmacokinetics of Rifampicin in Japanese Pulmonary Tuberculosis Patients 

Nishimura T et al.

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In Japan, tuberculosis has been recognized as one of the major infections requiring urgent measures because of its high morbidity rate even now especially in elderly people suffering from tuberculosis during the past epidemic and its reactivation. Hence, many Japanese clinicians have made efforts to suppress the onset of tuberculosis and treat it effectively. The objectives of this study are to (1) identify covariate(s) that may explain the variation of rifampicin, which is the key antitubercular agent, under the steady-state by evaluating its population pharmacokinetics and (2) to propose an appropriate dosing method of rifampicin to Japanese patients. 

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Drug Research

Issues per year : 12
Volume : 70
Year : 2020
ISSN : 2194-9379