Cyclic Peptides Synthesis with the Assistance of a Removable Activating Group
Contributors: Hisashi Yamamoto, An Wu
Ben-Lulu M, Gaster E, Libman A, Pappo D. * Ben-Gurion University of the Negev, Beer Sheva, Israel
Synthesis of Biaryl-Bridged Cyclic Peptides via Catalytic Oxidative Cross-Coupling Reactions
Angew. Chem. Int. Ed. 2020;
DOI: 10.1002/anie.201913305.
Key Words
oxidative cross-coupling - cyclic peptides - biaryl-bridged peptides - activating group
Significance
Biaryl-bridged cyclic peptides are becoming more and more important due to their biological activity. The authors have developed an efficient strategy to synthesize these peptides by introducing a removable activating group to increase reactivity in the oxidative cross-coupling step that forms the biaryl unit.
Comment
Although the authors have prepared some natural and nonnatural biaryl-bridged cyclic peptides in moderate total yields, this approach with a remarkable activating group (t-Bu) might have more synthetic uses.
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