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通过 C-H/N-H 键官能化和氧化环化合成含氮杂环化合物的最新发展 2022-01-07
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Synlett 2019; 30(09): 1026-1036
DOI: 10.1055/s-0037-1611476

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Xiang LiuYu HuangXu MengJihui LiDong WangYongxin ChenDong TangBaohua Chen 

Recent Developments in the Synthesis of Nitrogen-Containing Heterocycles through C–H/N–H Bond Functionalizations and Oxidative Cyclization

通过 C-H/N-H 键官能化和氧化环化合成含氮杂环化合物的最新发展

含氮杂环化合物的合成和结构具有极大吸引力,因为这些化合物结构丰富、理化性质和生物性质多样。因此,开发改进方法,合成多官能团含氮杂环化合物一直是一个具有挑战性的目标。本文描述了在过去 15 年中,我们的实验室在发现 C-H/N-H 键官能化和含氮杂环化合物(氮丙啶类、吲哚类、中氮茚类、三唑类、咪唑类、噁唑、噻唑类、喹喔啉、三嗪类和吡啶类)合成中的氧化环化途径中的探索。

The synthesis and structure of nitrogen-containing heterocycles are fascinating because these compounds have a great richness of structural, physicochemical, and biological properties. Therefore, the development of improved ways for the synthesis of polyfunctional nitrogen-containing heterocycles continues to be a challenging goal. This account describes developments in the discovery of C–H/N–H bond functionalization and oxidative cyclization procedures for the synthesis of nitrogen-containing heterocycles (aziridines, indoles, indolizines, triazoles, imidazoles, oxazoles, thiazoles, quinoxalines, triazines, and pyridines) in our laboratories during the last 15 years.

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本刊是一份国际期刊,以个性化短评和初步简报的形式报告有机合成化学的研究成果和当前趋势。它涵盖了所有涉及有机合成的科研领域,包括催化、有机金属、医药、生物学和光化学,也包括其他相关学科,同时也可通过其发表科学原始数据。