Michaela Keuper, Hans-Ulrich Häring, Harald Staiger
Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor isoforms (FGFR1c and FGFR3c) and the co-factor beta-Klotho (KLB) to trigger downstream signaling pathways. In this review Keuper et al focus on circulating FGF21 levels in humans and their associations with disease and clinical parameters, focusing primarily on obesity and obesity-associated diseases such as type-2 diabetes.
Experimental and Clinical Endocrinology & Diabetes
Issues per year : 12 Volume : 128 Year : 2020 ISSN : 0947-7349