Planta Medica

Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo

Silva Oliveira AG et al.

This research investigated the constituents of Tapirira guianensis and its antitumor potential (in vitro and in vivo) in glioblastoma.

Chinese Medicine and Natural Products

Construction of Migraine Knowledge Graph Based on Diagnosis and Treatment Guidelines of Integrative Medicine

Yanhua Jiang, Shiqing Qiu, Zhuang Guo, Huiling Ren, Xiaoying Li, Dongping Gao, Zhiwei Jing, Junwen Wang

The objective was to transform the text data in migraine diagnosis and treatment guidelines into a visualized knowledge graph by using knowledge graph technology, visually display the clinical diagnosis and treatment process, and provide assistance for the standardization of diagnosis and treatment of migraine with integrative medicine.

Drug Research

Repurposing Drugs: An Empowering Approach to Drug Discovery and Development

Sahil Kumar, Vandana Roy

This review aims to present the evolution, benefits and drawbacks including current approaches, key players and the legal and regulatory hurdles in the field of drug repurposing.

Pharmaceutical Fronts

Multistep Synthesis of Paracetamol in Continuous Flow

Jian-Li Chen, Jing-Yu Hu, Qi-Fan Wang, Peng Ge, Quan-Hui Wang, Zi-Shuo Lou

Considering that using flow reactors in series may avoid the problems faced by batch reactors, the article presents the strategy to obtain paracetamol via a continuous flow technology.

Pharmacopsychiatry

Factors Associated with Antidepressant Effects of Ketamine: A Reanalysis of Double-Blind Randomized Placebo-Controlled Trial of Intravenous Ketamine for Treatment-Resistant Depression

Yonezawa K et al.

Predictors of treatment response to intravenous ketamine remain unclear in patients with treatment-resistant depression (TRD); therefore, this study aimed to clarify these predictors using the US National Institutes of Health database of clinical trials.