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Pharmacopsychiatry | Issue 3/2023 is ready! 2023-05-24

Issue 03 · Volume 56 · May 2023

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昼夜节律是一种生物振荡,即使在没有 "zeitgebers"(外部时间线索)的情况下也会持续下去,周期约为24小时。唤醒/睡眠周期的中断在许多精神疾病中很常见,导致睡眠障碍、疲劳综合征、认知功能障碍和其他精神病理学症状。

Kiehn及其同事的评论论文讨论了昼夜节律紊乱与精神疾病之间的联系。作者证明,不断积累的证据表明,昼夜节律和不同的神经递质系统在多个层面上相互作用。时钟基因机制的遗传改变--就像时钟系统的外部扰动(如轮班工人)--可能使个体容易发展为精神障碍。同时,神经功能的变化可能会对昼夜节律调节产生反馈。由于许多精神疾病与睡眠障碍有关,通过固定的唤醒/睡眠周期和光照疗法来稳定昼夜节律系统已被证明是一种有希望的治疗工具。此外,行为节律疗法(如人际和社会节律疗法)可以稳定患者的日常活动,并被证明与其他已确立的双相情感障碍的强化心理治疗方法一样成功。

Kiehn等人的评论是罗斯托克大学医学中心精神病学和心理治疗系第16届汉萨研讨会(The 16th Hanseatic Symposium of the Department of Psychiatry and Psychotherapy, University Medical Centre in Rostock)论文集一部分。该论文集关注当前昼夜节律性的研究进展。欢迎阅读。

Review

Circadian Clocks in the Regulation of Neurotransmitter Systems

Kiehn JT et al.

To anticipate and adapt to daily recurring events defined by the earth’s rotation such as light-dark and temperature cycles, most species have developed internal, so-called circadian clocks. These clocks are involved in the regulation of behaviors such as the sleep-wake cycle and the secretion of hormones and neurotransmitters. Disruptions of the circadian system affect cognitive functions and are associated with various diseases that are characterized by altered neurotransmitter signaling. In this review, we summarize the current knowledge about the interplay of the circadian clock and the regulation of psychiatric health and disease.

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