MOST CITED ARTICLES

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

Laridan et al.

Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. 

Next-Generation Sequencing and Emerging Technologies

Kumar et al.

Genetic sequencing technologies are evolving at a rapid pace with major implications for research and clinical practice. In this review, the authors provide an updated overview of next-generation sequencing (NGS) and emerging methodologies. NGS has tremendously improved sequencing output while being more time and cost-efficient in comparison to Sanger sequencing. 

Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation

Iba et al.

Disseminated intravascular coagulation (DIC) has been recognized as a deadly complication in sepsis, and its early recognition followed by appropriate management of the underlying infection are the current management strategies. The activation of coagulation, inflammation, and other pathways are fundamental host responses against infection but also produce injury to the host. Recent advances have helped define the critical roles of thrombus formation in overcoming infection.

Pulmonary Thrombosis: A Clinical Pathological Entity Distinct from Pulmonary Embolism?

Marongiu et al.

Since Virchow's autopsy studies in the mid-1800s, it has generally been believed that pulmonary embolism (PE) originated from the embolization of fibrin fragments from a deep venous thrombosis (DVT). However, a DVT is often not found in patients with PE (up to 50% of cases). Could fibrin form in the pulmonary vessels without coming from the periphery? In this review, the authors will try to support the hypothesis that a pulmonary thrombosis (PT) may develop.

Recommendations for Minimal Laboratory Testing Panels in Patients with COVID-19: Potential for Prognostic Monitoring

Favaloro, Lippi

A new infective outbreak, which has been finally defined as coronavirus disease 2019 (COVID-19), has now taken hold all around the world.